The Dr. Joseph Y. Porter House is a historic home in Key West, Florida. It is located at 429 Caroline Street. The original construction was built in 1838 by Judge James Webb. The house is best known as the lifelong home of Dr. Joseph Yates Porter Jr. His father bought the property in 1845. Porter lived in the home for 80 years, dying in the same room he was born. He was Key West's first native-born physician and Florida's first Public Health Officer from 1889–1917. He was instrumental in controlling yellow fever, reforming sanitation and quarantine practices, and initiating health legislation. Porter was among the first physicians to recognize yellow fever as transmissible by mosquitoes.