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. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. PEPTIDE YY 189 An examination of the mechanisms by which PYY in- hibits gastric secretion has given a clue to the cellular site of action of PYY (Pappas el al, 1986b). Although PYY is a potent inhibitor of meal-stimulated acid secretion in the dog. it exerts no inhibitory effect on the acid secretory response to cholinomimetics such as carbachol. In addi- tion it is, at best, a weak inhibitor of acid secretion stimu- lated by pentagastrin and histamine. As PYY does not block the action of the known hormonal and neurotrans- m

. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. PEPTIDE YY 189 An examination of the mechanisms by which PYY in- hibits gastric secretion has given a clue to the cellular site of action of PYY (Pappas el al, 1986b). Although PYY is a potent inhibitor of meal-stimulated acid secretion in the dog. it exerts no inhibitory effect on the acid secretory response to cholinomimetics such as carbachol. In addi- tion it is, at best, a weak inhibitor of acid secretion stimu- lated by pentagastrin and histamine. As PYY does not block the action of the known hormonal and neurotrans- m Stock Photo
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. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. PEPTIDE YY 189 An examination of the mechanisms by which PYY in- hibits gastric secretion has given a clue to the cellular site of action of PYY (Pappas el al, 1986b). Although PYY is a potent inhibitor of meal-stimulated acid secretion in the dog. it exerts no inhibitory effect on the acid secretory response to cholinomimetics such as carbachol. In addi- tion it is, at best, a weak inhibitor of acid secretion stimu- lated by pentagastrin and histamine. As PYY does not block the action of the known hormonal and neurotrans- mitter secretogogues at the level of the parietal cell, we must assume that its effects on acid secretion are indirect. In contrast to its lack of potency in blocking the effects of external secretogogues, PYY is a very potent inhibitor of cephalic phase acid secretion, causing 95% inhibition of acid secretion induced by sham feeding in dogs. These results suggest that PYY inhibits gastric function by in- hibiting vagal tone on the stomach; as such it appears to function as an endocrine neuromodulator. Physiological Significance of PYY Over a century ago, Ewald and Boas (1886) noted that the addition of olive oil to a test meal of gruel inhibited acid secretion and delayed gastric emptying in man. One of Pavlov's students went on to demonstrate that this in- hibition of acid secretion could only be demonstrated if fat was allowed to pass beyond the stomach (Gregory, 1962). In 1930, Kosaka and Lim (1933) isolated an in- hibitor of gastric secretion from the mucosa of both the small and large intestine, which they termed "enterogas- trone." Despite Kosaka and Lim's initial observation (Kosaka and Lim, 1933) that colonic extracts were as po- tent as jejunal extracts, the search for enterogastrone largely centered on the small intestine. Interest in the dis- tal bowel as the site of release of the gastric inhibitor (col- ogastrone) was rekindled by the demonstration (Seal

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