Tau protein in Alzheimer's disease,illustration.Pathological phosphorylation (yellow) of Tau proteins (red-orange) by kinases (blue-purple) affect nerve cells in what is called a neurofibrillary tangle.This illustration shows pathological aggregations of tau proteins causing disintegration of a microtubule (cylindrical structure).The transport of synaptic vesicles (orange-blue spheres,one at top left) is also interrupted.A neurofibrillary tangle consists of abnormal aggregates and insoluble fibres of the protein tau.

- Image ID: PT5HK3