Rabies Virus, Negri Bodies, LM
Contributor:Science History Images / Alamy Stock Photo
File size:28.9 MB (1.5 MB Compressed download)
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Dimensions:3900 x 2590 px | 33 x 21.9 cm | 13 x 8.6 inches | 300dpi
This image could have imperfections as it’s either historical or reportage.
LM depicts the histopathological changes associated with rabies encephalitis prepared using an H&E stain. Note the Negri bodies, which are cellular inclusions found most frequently in the pyramidal cells of Ammon's horn, and the Purkinje cells of the cerebellum. They are also found in the cells of the medulla and various other ganglia. The virus infects the central nervous system, causing encephalopathy and ultimately death. The number of rabies-related human deaths in the US has declined from more than 100 annually at the turn of the century to one or two per year in the 1990's. Modern day prophylaxis has proven nearly 100% successful. Early symptoms of rabies in humans are nonspecific, consisting of fever, headache, and general malaise. As the disease progresses, neurological symptoms appear and may include insomnia, anxiety, confusion, slight or partial paralysis, excitation, hallucinations, agitation, hyper-salivation, difficulty swallowing, and hydrophobia (fear of water). Death occurs within days of the onset of symptoms.