The town has three stations, the main railway station (known simply as Motherwell), Airbles and Shieldmuir. The main station runs on the West Coast Main Line from Glasgow to London and on the East Coast Main Line via Edinburgh and Newcastle, and is located next to Motherwell Shopping Centre.
National train operators; Virgin Trains, CrossCountry and TransPennine Express, pass through the main station, but not all stop there. The station is also served by Abellio ScotRail who provide direct services to Carstairs, Coatbridge Central, Cumbernauld, Dalmuir, Edinburgh, Lanark, Milngavie and North Berwick. Virgin Trains East Coast also provide a direct daily service between London Kings Cross and Glasgow Central that stops at Motherwell. The smaller station in the Airbles suburb of Motherwell only runs on the line to Dalmuir via Glasgow Central low level and Hamilton Central; however, it is closer to the Civic Centre and Fir Park stadium than the main-line station. That station is served by First ScotRail.
The (now defunct) firm of Hurst Nelson was a major railway rolling stock manufacturer based in the town. The company built trains for the London Underground, as well as main line railways