HIV-1 reverse transcriptase inhibition, illustration. The human immunodeficiency virus single-stranded RNA genome is converted into double-stranded DNA by the viral reverse transcriptase (blue) and then the DNA is integrated in the DNA of an infected human cell. The reverse transcriptase is one of the main targets to disrupt the virus multiplication through an inhibitor. There are nucleoside and nucleotide inhibitors and non-nucleoside analogue inhibitors. One of these inhibitors (yellow) is shown binding to the reverse transcriptase.