Cayo Largo del Sur, or simply Cayo Largo ("Long Cay"), is a small resort island in Cuba, off the south coast of the northwestern part of the main island in the Caribbean Sea. The cay is about 25 kilometers (16 mi) long and 3 kilometers (1.9 mi) wide and is the second largest island in the Canarreos Archipelago. Cayo Largo is part of the special municipality of Isla de la Juventud.
Christopher Columbus is said to have visited the island on his second expedition in 1494, and Sir Francis Drake may have also stopped on the island during his circumnavigation of the globe. Pirates also likely used the island as a base. Today, pristine beach, scuba diving, and wildlife draw tourists to the island, but no people live there permanently; locals who work in the hotels stay for about 20 days, then return to their families on nearby islands. There are five all-inclusive resort hotels on the island. Flights from Miami, Argentina, Italy, and Canada serve the island. A large catamaran style ferry provides surface transportation.